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• A movable long-term implantable soft microfibre for dynamic bioelectronics AI翻译
  作者：Xie, Ruijie; Han, Fei; Yu, Qianhengyuan; Li, Dong; Han, Xu; Xu, Xiaolong; Yu, Huan; Huang, Jianping; Zhou, Xiaomeng; Zhao, Hang; Deng, Xinping; Tian, Qiong; Li, Qingsong; Li, Hanfei; Zhao, Yang; Ma, Guoyao; Li, Guanglin; Zheng, Hairong; Zhu, Meifang; Yan, Wei; Xu, Tiantian; Liu, Zhiyuan
  作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Xiamen University; Donghua University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Shenzhen University of Advanced Technology; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Shandong University
  摘要：Long-term implantable bioelectronics offer a powerful means to evaluate the function of the nervous system and serve as effective human-machine interfaces1, 2-3. Here, inspired by earthworms, we introduce NeuroWorm-a soft, stretchable and movable fibre sensor designed for bioelectronic interface. Our approach involves rolling to transform 2D bioelectronic devices into 1D NeuroWorm, creating a multifunctional microfibre that houses longitudinally distributed electrode arrays for both bioelectri...
• Excised DNA circles from V(D)J recombination promote relapsed leukaemia AI翻译
  作者：Gao, Zeqian; Scott, James N. F.; Edwards, Matthew P.; Casey, Dylan; Wang, Xiaoling; Gillen, Andrew D.; Ryan, Sarra; Russell, Lisa J.; Moorman, Anthony V.; de Tute, Ruth; Cargo, Catherine; Ford, Anthony M.; Westhead, David R.; Boyes, Joan
  作者单位：University of Leeds; Newcastle University - UK; Newcastle University - UK; Saint James's University Hospital; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; University of Leeds; University of Leeds; Southmead Hospital; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; University of Glasgow
  摘要：Extrachromosomal DNA amplification is associated with poor cancer prognoses1. Large numbers of excised signal circles (ESCs) are produced as by-products of antigen receptor rearrangement during V(D)J recombination2,3. However, current dogma states that ESCs are progressively lost through cell division4. Here we show that ESCs replicate and persist through many cell generations and share many properties in common with circular extrachromosomal DNAs. Increased ESC copy numbers at diagnosis of B ...
• SuFEx-based antitubercular compound irreversibly inhibits Pks13 AI翻译
  作者：Krieger, Inna V.; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B.; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A. L.; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L.; Massoudi, Lisa M.; Woolhiser, Lisa K.; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R.; Kandula, Dilipkumar Reddy; McCabe, Jacob W.; Guo, Taijie; Alland, David; Boshoff, Helena I.; Schnappinger, Dirk; Robertson, Gregory T.; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G.; Joseph, Sean B.; Love, Melissa S.; Sharpless, K. Barry; Petrassi, H. Michael; Chatterjee, Arnab K.; Sacchettini, James C.; McNamara, Case W.
  作者单位：Texas A&M University System; Texas A&M University College Station; Cornell University; Weill Cornell Medicine; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Newark; Scripps Research Institute; Trudeau Institute; Colorado State University System; Colorado State University Fort Collins; Texas A&M University System; Texas A&M University College Station; Shanghai Jiao Tong University; National Institutes of Health (NIH) - USA; Scripps Research Institute; Scripps Research Institute
  摘要：Mycobacterium tuberculosis (Mtb) remains the world's deadliest bacterial pathogen1. There is an urgent medical need to develop new drugs that shorten the treatment duration to combat widespread multi-drug-resistant and extensive-drug-resistant Mtb. Here, we present a preclinical covalent compound, CMX410, that contains an aryl fluorosulfate (SuFEx)2 warhead and uniquely targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis. CMX410 is equipotent against drug...
• A generic non-invasive neuromotor interface for human-computer interaction AI翻译
  作者：Kaifosh, Patrick; Reardon, Thomas R.; Allen, Brian D.; Anderson, Chris; Arnoud, Sacha; Arora, Rahul; Atray, Mridu; Awad, Lana; Ayerbe, Francisco; Baker, Christopher; Baker, Nicholas; Barachant, Alexandre; Bard, Philip; Beltran, Wilman Pimentel; Berenzweig, Adam; Bhasin, Rohin; Bienkowski, Joe; Bittner, Sean; Boegner, Luke; Bolarinwa, Anu; Bosley, Don; Bracaglia, Matthew; Braecklein, Mario; Brandwein, Maclyn; Bravate, Joe; Butler, Matt; Calhoun, Adam J.; Chang, Chia-Jung; Chenet, Daniel; Chester, Joshua; Chiarito, Rudi; Chitnis, Rohan; Choi, John; Chun, Won; Chung, Jeremiah; Connors, James; Costa, Jota; Cramer, Mark; Cunningham, Raven; Cusack, William F.; Danielson, Nathan; Davidson, Thomas J.; De Araujo, Bruno; Dimaiolo, Bob; Draves, Scott; Du, Alan; Edelson, Zaina; Enemuo, Phina; Fahmi, Mina; Farsad, Nariman; Farshchian, Ali; Feliz, Randy; Fine, Jake; Formento, Emanuele; Freeman, Dustin; Fu, Jianing; Gagnon-Audet, Jean-Christophe; Gajurel, Rupesh; Gamutan, Jonathan; Gao, Sida; Garcia, Jonateal; Gayraud, Nathalie Therese Helene; Ghani, Minha; Ghosh, Sayan; Gidwani, Vickram; Giebisch, Danny; Gimler, Greg; Gramfort, Alexandre; Grosberg, Lauren; Gunther, Bryn; Guo, Ning; Gupta, Chetan; Kaya, Sinem Guven; Ha, Austin; Hadjer, Katarina; Hernandez, Carlos Xavier; Hertz, Stav; Hewitt, Carl; Hill, Daniel N.; Hong, Kirak; Hong, Lillian; Hou, Helen; Hruda, Stepan; Hsieh, Alex; Hsiung, Vivian; Huang, Rongqing; Hui, Yue; Hulet, Hazel; Islam, Shaker; Jayaram, Vinay; Jiang, Connie; Jiang, Xiaodong; Juarez, Brooke; Jun, James Jaeyoon; Jun, Na Young; Kadakia, Nirag; Kakar, Nishant; Kamdar, Ajay; Kao, Ta-Chu; Kober, Steven; Koh, Tw; Koshy, Christina Shabu; Lawn, Andrzej; Lee, Claire; Lee, Jennifer; Lee, Jinhyung; Lee, Juheui Amy; Li, Tiffanie; Liao, Jonathan; Liu, Yingru; Liu, Yuxuan; Lively, Saar; London, Kati; Louie, Roddy; Luongo, Francisco; Maczak, Attila; Maheswaranathan, Niru; Mandel, Michael; Marshall, Jesse; Marshall, Najja; Martincik, Mirek; Masse, Nicolas Yvan; McAnearney, Stephen; McHugh, Ashley; Menendez, Jorge Aurelio; Merel, Josh; Miller, David; Milyavskiy, Ilya; Monti, Ricardo Pio; Moore, Sean; Morin, Yonathan; Morrell, Brock; Morrison, Dano; Moschella, Anthony; Mulumudi, Suman; Muth, Conner; Naik, Krunal; Nakagaki, Norris; Nathan, Ajay; Nelson, Romario; Ngeo, Jimson; Nguyen, Keven; O'Connor, Luke; Ohayon, Shay; Orchard, Garrick; Osborn, Chris; Otchy, Timothy M.; Owolabi, Emmanuella; Packer, Adam M.; Pailla, Tejaswy; Paredes, Julia; Parker, Sean; Peixoto, Diogo; Perez, Matias; Perez, Zavion; Pierard, Adrien; Plaza, Stephen M.; Plotkin, Natalie; Pnevmatikakis, Eftychios; Pool, Brandon; Puri, Shanil; Rajani, Sunaina; Fuentes, Jose Ramirez; Rojas, Julian Ramos; Ranjan, Tanvi; Reardon, Devin; Reid, Jonathan; Reisman, Jason; Rivera, Lain Warawao Nemo Mora y; Rolotti, Sebi; Rosenkranz, Andrew; Roth, Ian; Roy, Likhon; Rubin, Ran; Rudnicki, Alexander; Russell, Sam; Russo, Abby; Sacra, James; Sadoughi, Amir; Salim, Roxanna; Savane, Aichatou; Schlager, Collin; Schwab, David; Seely, Jeffrey; Seltzer, Mike; Sergin, Nurettin Dorukhan; Shah, Ami; Shah, Anish; Shamash, Philip; Sharma, Vandita; Shen, Stephie; Shi, Kevin; Shiah, Olivia; Siahpoosh, Yasmin; Siddiqi, Noor; Simpson, Jeremy; Singh, Gagandip; Sivakumar, Viswanath; Smith, Jeff; Sofuoglu, Seyyid Emre; Song, Ivy Jiyoung; Springer, Morgan; Spurr, Adrian; Stefanini, Fabio; Stout, Connor; Strauss, Emanuel; Suresh, Swetha; Suri, Ananya; Sussillo, David; Tang, Ziyi; Tank, Vikram; Tannady, Jesslyn; Tapia, Aliqyan; Tasci, Tugce; Tesileanu, Tiberiu; Tiwari, Aman; Tiwari, Anoushka; Tong, Calvin; Tormis, Blizelle; Trabulsi, Julia; Tsering, Migmar; Urquhart, Kyle; Walkington, Peter; Wang, Megan; Wang, Renxiong; Wang, Zhuo; Warden, Christy; Warren, Richard; Warriner, Claire L.; Weiss, Ron J.; Wetmore, Daniel Z.; White, Ezri; Wiebe, Christopher; Williams, Steve; Xing, Yuguan; Ye, Chris; Yembarwar, Akshay; Yuan, Shuibenyang; Zawadzki, Michael; Zhang, Mingrui; Zhao, Jiesi; Zheng, Kevin; Zhong, Joseph; Zhou, Lei; Zlobinsky, Danny
  摘要：Since the advent of computing, humans have sought computer input technologies that are expressive, intuitive and universal. While diverse modalities have been developed, including keyboards, mice and touchscreens, they require interaction with a device that can be limiting, especially in on-the-go scenarios. Gesture-based systems use cameras or inertial sensors to avoid an intermediary device, but tend to perform well only for unobscured movements. By contrast, brain-computer or neuromotor int...
• GPS timekeeping is increasingly vulnerable: here's how to deliver future-proofed time AI翻译
  作者：Lobo, Leon; Paul, Douglas; Velu, Chander
  作者单位：University of Glasgow; University of Cambridge
• The Hidden Link between Racism and Alzheimer's Risk AI翻译
  作者：Madhusoodanan, Jyoti
  摘要：Black Americans face a significantly higher risk of Alzheimer's and other dementias than white Americans. Researchers are working to find out why that is and how to intervene.
• Disease-associated astrocyte epigenetic memory promotes CNS pathology (vol 627, pg 865, 2024) AI翻译
  作者：Lee, Hong-Gyun; Rone, Joseph M.; Li, Zhaorong; Akl, Camilo Faust; Shin, Seung Won; Lee, Joon-Hyuk; Flausino, Lucas E.; Pernin, Florian; Chao, Chun-Cheih; Kleemann, Kilian L.; Srun, Lena; Illouz, Tomer; Giovannoni, Federico; Charabati, Marc; Sanmarco, Liliana M.; Kenison, Jessica E.; Piester, Gavin; Zandee, Stephanie E. J.; Antel, Jack P.; Rothhammer, Veit; Wheeler, Michael A.; Prat, Alexandre; Clark, Iain C.; Quintana, Francisco J.
• Multiple oestradiol functions inhibit ferroptosis and acute kidney injury (AUG, 10.1038/s41586-025-09389-x, 2025) AI翻译
  作者：Tonnus, Wulf; Maremonti, Francesca; Gavali, Shubhangi; Schlecht, Marlena Nastassja; Gembardt, Florian; Belavgeni, Alexia; Leinung, Nadja; Flade, Karolin; Bethe, Natalie; Traikov, Sofia; Haag, Anne; Schilling, Danny; Penkov, Sider; Mallais, Melodie; Gaillet, Christine; Meyer, Claudia; Katebi, Melika; Ray, Anushka; Gerhardt, Louisa M. S.; Brucker, Anne; Becker, Jorunn Naila; Tmava, Mirela; Schlicker, Lisa; Schulze, Almut; Himmerkus, Nina; Shevchenko, Andrej; Peitzsch, Mirko; Barayeu, Uladzimir; Nasi, Sonia; Putz, Juliane; Korach, Kenneth S.; Neugarten, Joel; Golestaneh, Ladan; Hugo, Christian; Becker, Jan Ulrich; Weinberg, Joel M.; Lorenz, Svenja; Proneth, Bettina; Conrad, Marcus; Wolf, Eckhard; Plietker, Bernd; Rodriguez, Raphael; Pratt, Derek A.; Dick, Tobias P.; Fedorova, Maria; Bornstein, Stefan R.; Linkermann, Andreas
  作者单位：Technische Universitat Dresden; Carl Gustav Carus University Hospital; Ruprecht Karls University Heidelberg; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Max Planck Society; Technische Universitat Dresden; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Ottawa; UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Helmholtz Association; German Cancer Research Center (DKFZ); University of Kiel; Max Planck Society; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Technische Universitat Dresden; Carl Gustav Carus University Hospital; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Montefiore Medical Center; Yeshiva University; University of Cologne; University of Michigan System; University of Michigan; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; University of Munich; German Center for Diabetes Research (DZD); Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of London; King's College London; Technische Universitat Dresden; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Yeshiva University
• Chemists cram record nine metals into trendy 2D material AI翻译
  作者：Bourzac, Katherine
• High-density soft bioelectronic fibres for multimodal sensing and stimulation AI翻译
  作者：Khatib, Muhammad; Zhao, Eric Tianjiao; Wei, Shiyuan; Park, Jaeho; Abramson, Alex; Bishop, Estelle Spear; Thomas, Anne-Laure; Chen, Chih-Hsin; Emengo, Pamela; Xu, Chengyi; Hamnett, Ryan; Root, Samuel E.; Yuan, Lei; Wurdack, Matthias J.; Zaluska, Tomasz; Lee, Yeongjun; Parkatzidis, Kostas; Yu, Weilai; Chakhtoura, Dorine; Kim, Kyun Kyu; Zhong, Donglai; Nishio, Yuya; Zhao, Chuanzhen; Wu, Can; Jiang, Yuanwen; Zhang, Anqi; Li, Jinxing; Wang, Weichen; Salimi-Jazi, Fereshteh; Rafeeqi, Talha A.; Hemed, Nofar Mintz; Tok, Jeffrey B. -H.; Qian, Xiang; Chen, Xiaoke; Kaltschmidt, Julia A.; Dunn, James C. Y.; Bao, Zhenan
  作者单位：Stanford University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Emory University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Michigan State University; Michigan State University; Stanford University; Stanford University; Stanford University
  摘要：There is an increasing demand for multimodal sensing and stimulation bioelectronic fibres for both research and clinical applications1,2. However, existing fibres suffer from high rigidity, low component layout precision, limited functionality and low density of active components. These limitations arise from the challenge of integrating many components into one-dimensional fibre devices, especially owing to the incompatibility of conventional microfabrication methods (for example, photolithog...