-
作者：Kuk, Anthony Y. C.; Tan, C. C.
作者单位：National University of Singapore; National University of Singapore
摘要：In modeling disease transmission there is much emphasis on how many people are infected but less attention is paid to when the infections occur, and the unrealistic assumption of constant infectiousness is often made. We propose a missing data formulation that enables us to apply the ECME algorithm to estimate a discretized intensity function of an inhomogeneous Poisson process. This approach requires interval-censored data only, but known infection times can be incorporated as well. We apply ...
-
作者：Cucala, Lionel; Marin, Jean-Michel; Robert, Christian P.; Titterington, D. M.
作者单位：Universite Paris Saclay; Universite PSL; Universite Paris-Dauphine; University of Glasgow
摘要：The k-nearest-neighbor (knn) procedure is a well-known deterministic method used in supervised classification. This article proposes a reassessment of this approach as a statistical technique derived from a proper probabilistic model; in particular, we modify the assessment found in Holmes and Adams, and evaluated by Manocha and Girolami, where the underlying probabilistic model is not completely well defined. Once provided with a clear probabilistic basis for the knn procedure, we derive comp...
-
作者：Guo, Feng; Dey, Dipak K.; Holsinger, Kent E.
作者单位：Virginia Polytechnic Institute & State University; University of Connecticut; University of Connecticut
摘要：The distribution of genetic variation among populations is conveniently measured by Wright's F-ST,. which is a scaled variance taking on values in [0,I]. For certain types of genetic markers and for single-nucleotide polymorphisms (SNPs) in particular, it is reasonable to presume that allelic differences at most loci are selectively neutral. For such loci, the distribution of genetic variation among populations is determined by the size of local populations, the pattern and rate of migration a...
-
作者：Higdon, D.
作者单位：United States Department of Energy (DOE); Los Alamos National Laboratory
-
作者：Zhang, Junni L.; Rubin, Donald B.; Mealli, Fabrizia
作者单位：Peking University; Harvard University; University of Florence
摘要：Government-sponsored job-training programs must be subject to evaluation to assess whether their effectiveness justifies their cost to the public. The evaluation usually focuses on employment and total earnings, although the effect on wages is also of interest, because this effect reflects the increase in human capital due to the training program, whereas the effect on total earnings may be simply reflecting the increased likelihood of employment without any effect on wage rates. Estimating th...
-
作者：Rueda, Cristina; Fernandez, Miguel A.; Das Peddada, Shyamal
作者单位：Universidad de Valladolid; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
摘要：Motivated by a problem encountered in the analysis of cell cycle gene expression data. this article deals with the estimation of parameters subject to order restrictions on a unit circle. A normal eukaryotic cell cycle has four major phases, during cell division, and a cell cycle gene has its peak expression (phase angle) during the phase that may correspond to its biological function. Because the phases are ordered along a circle, the phase angles of cell cycle genes are ordered unknown param...
-
作者：Park, Byeong U.; Mammen, Enno; Haerdle, Wolfgang; Borak, Szymon
作者单位：Seoul National University (SNU); University of Mannheim; Humboldt University of Berlin
摘要：High-dimensional regression problems, which reveal dynamic behavior, are typically analyzed by time propagation of a few number of factors. The inference on the whole system is then based on the low-dimensional time series analysis. Such high-dimensional problems occur frequently in many different fields of science. In this article we address the problem of inference when the factors and factor loadings are estimated by semiparametric methods. This more flexible modeling approach poses an impo...
-
作者：Murphy, S. A.; Bingham, D.
作者单位：University of Michigan System; University of Michigan; Simon Fraser University
摘要：Dynamic treatment regimes are time-varying treatments that individualize sequences of treatments to the patient. The construction of dynamic treatment regimes is challenging because a patient will be eligible for some treatment components only if he has not responded (or has responded) to other treatment components. In addition, there are usually a number of potentially useful treatment components and combinations thereof. In this article, we propose new methodology for identifying promising c...
