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作者：Chaffee, Paul; van der Laan, Mark
作者单位：University of California System; University of California Berkeley
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作者：Hahn, Ute
作者单位：Aarhus University
摘要：In this study, a new test is proposed for the hypothesis that two (or more) observed point patterns are realizations of the same spatial point process model. To this end, the point patterns are divided into disjoint quadrats, on each of which an estimate of Ripley's K-function is calculated. The two groups of empirical K-functions are compared by a permutation test using a Studentized test statistic. The proposed test performs convincingly in terms of empirical level and power in a simulation ...
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作者：Sardy, Sylvain
作者单位：University of Geneva
摘要：The proposed smooth blockwise iterative thresholding estimator (SBITE) is a model selection technique defined as a fixed point reached by iterating a likelihood gradient-based thresholding function. The smooth James-Stein thresholding function has two regularization parameters lambda and nu, and a smoothness parameter s. It enjoys smoothness like ridge regression and selects variables like lasso. Focusing on Gaussian regression, we show that SBITE is uniquely defined, and that its Stein unbias...
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作者：Wang, Lu; Rotnitzky, Andrea; Lin, Xihong; Millikan, Randall E.; Thall, Peter F.
作者单位：University of Michigan System; University of Michigan; Universidad Torcuato Di Tella; Harvard University; Harvard T.H. Chan School of Public Health; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas Health Science Center Houston
摘要：We present new statistical analyses of data arising from a clinical trial designed to compare two-stage dynamic treatment regimes (DTRs) for advanced prostate cancer. The trial protocol mandated that patients be initially randomized among four chemotherapies, and that those who responded poorly be re-randomized to one of the remaining candidate therapies. The primary aim was to compare the DTRs' overall success rates, with success defined by the occurrence of successful responses in each of tw...
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作者：Wang, Lu; Rotnitzky, Andrea; Lin, Xihong; Millikan, Randall E.; Thall, Peter F.
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作者：Hu, Zonghui; Follmann, Dean A.; Qin, Jing
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
摘要：When estimating the marginal mean response with missing observations, a critical issue is robustness to model misspecification. In this article, we propose a semiparametric estimation method with extended double robustness that attains the optimal efficiency under less stringent requirement for model specifications than the doubly robust estimators. In this semiparametric estimation, covariate information is collapsed into a two-dimensional score S. with one dimension for (i) the pattern of mi...
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作者：Johnson, Valen E.; Rossell, David
作者单位：University of Texas System; UTMD Anderson Cancer Center; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona
摘要：Standard assumptions incorporated into Bayesian model selection procedures result in procedures that are not competitive with commonly used penalized likelihood methods. We propose modifications of these methods by imposing nonlocal prior densities on model parameters. We show that the resulting model selection procedures are consistent in linear model settings when the number of possible covariates p is bounded by the number of observations n, a property that has not been extended to other mo...
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作者：Sobel, Michael E.
作者单位：Columbia University
摘要：Social scientists have generated a large and inconclusive literature on the effect(s) of marriage on men's wages. Researchers have hypothesized that the wage premium enjoyed by married men may reflect both a tendency for more productive men to marry and an effect of marriage on productivity. To sort out these explanations, researchers have used fixed effects regression models for panel data to adjust for selection on unobserved time-invariant confounders, interpreting coefficients for the time...
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作者：Clarke, Paul S.; Windmeijer, Frank
作者单位：University of Bristol; University of Bristol; University of Bristol
摘要：Instrumental variables (IVs) can be used to construct estimators of exposure effects on the outcomes of studies affected by nonignorable selection of the exposure. Estimators that fail to adjust for the effects of nonignorable selection will be biased and inconsistent. Such situations commonly arise in observational studies, but are also a problem for randomized experiments affected by nonignorable noncompliance. In this article, we review IV estimators for studies in which the outcome is bina...
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作者：Telesca, Donatello; Mueller, Peter; Kornblau, Steven M.; Suchard, Marc A.; Ji, Yuan
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Texas System; University of Texas Austin; University of Texas System; UTMD Anderson Cancer Center
摘要：High-throughput functional proteomic technologies provide a way to quantify the expression of proteins of interest. Statistical inference centers on identifying the activation state of proteins and their patterns of molecular interaction formalized as dependence structure. Inference on dependence structure is particularly important when proteins are selected because they are part of a common molecular pathway. In that case, inference on dependence structure reveals properties of the underlying...
