作者：Taddy, Matt
作者单位：University of Chicago
摘要：Text data, including speeches, stories, and other document forms, are often connected to sentiment variables that are of interest for research in marketing, economics, and elsewhere. It is also very high dimensional and difficult to incorporate into statistical analyses. This article introduces a straightforward framework of sentiment-sufficient dimension reduction for text data. Multinomial inverse regression is introduced as a general tool for simplifying predictor sets that can be represent...
作者：Zhang, Jin; Braun, Thomas M.
作者单位：University of Michigan System; University of Michigan
摘要：In traditional schedule or dose schedule finding designs, patients are assumed to receive their assigned dose schedule combination throughout the trial even though the combination may be found to have an undesirable toxicity profile, which contradicts actual clinical practice. Since no systematic approach exists to optimize intrapatient dose schedule assignment, we propose a Phase I clinical trial design that extends existing approaches to optimize dose and schedule solely between patients by ...
