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作者：Xiao, Luo; Thurston, Sally W.; Ruppert, David; Love, Tanzy M. T.; Davidson, Philip W.
作者单位：Johns Hopkins University; University of Rochester; Cornell University; Cornell University; University of Rochester; University of Rochester; University of Rochester
摘要：The Seychelles Child Development Study (SCDS) examines the effects of prenatal exposure to methylmercury on the functioning of the central nervous system. The SCDS data include 20 outcomes measured on 9-year-old children that can be classified broadly in four outcome classes or domains: cognition, memory, motor, and social behavior. Previous analyses and scientific theory suggest that these outcomes may belong to more than one of these domains, rather than only a single domain as is frequently...
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作者：Rashid, Naim; Sun, Wei; Ibrahim, Joseph G.
作者单位：University of North Carolina; University of North Carolina Chapel Hill
摘要：In DAB (DNA after enrichment)-seq experiments, genomic regions related with certain biological processes are enriched/isolated by an assay and are then sequenced on a high-throughput sequencing platform to determine their genomic positions. Statistical analysis of DAE-seq data aims to detect genomic regions with significant aggregations of isolated DNA fragments (enriched regions) versus all the other regions (background). However, many Confounding factors may influence DAE-seq signals. In add...
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作者：Allen, Genevera I.; Grosenick, Logan; Taylor, Jonathan
作者单位：Rice University; Rice University; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College Medical Hospital; Stanford University; Stanford University
摘要：Variables in many big-data settings are structured, arising, for example, from measurements on a regular grid as in imaging and time series or from spatial-temporal measurements as in climate studies. Classical multivariate techniques ignore these structural relationships often resulting in poor performance. We propose a generalization of principal components analysis (PCA) that is appropriate for massive datasets with structured variables or known two-way dependencies. By finding the best low...
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作者：Joyce, Patrick M.; Malec, Donald; Little, Roderick J. A.; Gilary, Aaron; Navarro, Alfredo; Asiala, Mark E.
作者单位：Centers for Disease Control & Prevention - USA; CDC National Center for Health Statistics (NCHS); University of Michigan System; University of Michigan
摘要：Section 203 of the Voting Rights Act includes provisions requiring the use of election materials in languages other than English for states or political subdivisions, specifically, when a minimum number of voting age U.S. citizens of specified language minority groups who are unable to speak English very well and have obtained less than a fifth-grade education is met. Data on these characteristics are provided by the 2010 Census and the American Community Survey (ACS), a general purpose sample...
