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作者：Fronczyk, Kassandra; Kottas, Athanasios
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of California System; University of California Santa Cruz
摘要：We develop a Bayesian nonparametric mixture modeling framework for replicated count responses in dose-response settings. We explore this methodology for modeling and risk assessment in developmental toxicity studies, where the primary objective is to determine the relationship between the level of exposure to a toxic chemical and the probability of a physiological or biochemical response, or death. Data from these experiments typically involve features that cannot be captured by standard param...
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作者：Gelman, Andrew; Vehtari, Aki
作者单位：Columbia University; Aalto University
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作者：Hao, Ning; Zhang, Hao Helen
作者单位：University of Arizona
摘要：In ultrahigh-dimensional data analysis, it is extremely challenging to identify important interaction effects, and a top concern in practice is computational feasibility. For a dataset with n observations and p predictors, the augmented design matrix including all linear and order-2 terms is of size n x (p(2) + 3p)/2. When p is large, say more than tens of hundreds, the number of interactions is enormous and beyond the capacity of standard machines and software tools for storage and analysis. ...
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作者：Hansen, Ben B.; Rosenbaum, Paul R.; Small, Dylan S.
作者单位：University of Michigan System; University of Michigan; University of Pennsylvania
摘要：Clustered treatment assignment occurs when individuals are grouped into clusters prior to treatment and whole clusters, not individuals, are assigned to treatment or control. In randomized trials, clustered assignments may be required because the treatment must be applied to all children in a classroom, or to all patients at a clinic, or to all radio listeners in the same media market. The most common cluster randomized design pairs 2S clusters into S pairs based on similar pretreatment covari...
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作者：Janson, Lucas; Rajaratnam, Bala
作者单位：Stanford University; Stanford University; Stanford University
摘要：Great strides have been made in the field of reconstructing past temperatures based on models relating temperature to temperature-sensitive paleoclimate proxies. One of the goals of such reconstructions is to assess if current climate is anomalous in a millennial context. These regression-based approaches model the conditional mean of the temperature distribution as a function of paleoclimate proxies (or vice versa). Some of the recent focus in the area has considered methods that help reduce ...
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作者：Jung, Yoonsuh; Huang, Jianhua Z.; Hu, Jianhua
作者单位：University of Waikato; Texas A&M University System; Texas A&M University College Station; Capital University of Economics & Business; University of Texas System; UTMD Anderson Cancer Center
摘要：In genome-wide association studies, the primary task is to detect biomarkers in the form of single nucleotide polymorphisms (SNPs) that have nontrivial associations with a disease phenotype and some other important clinical/environmental factors. However, the extremely large number of SNPs compared to the sample size inhibits application of classical methods such as the multiple logistic regression. Currently, the most commonly used approach is still to analyze one SNP at a time. In this artic...
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作者：Plumlee, Matthew
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：Random field models have been widely employed to develop a predictor of an expensive function based on observations from an experiment. The traditional framework for developing a predictor with random field models can fail due to the computational burden it requires. This problem is often seen in cases where the input of the expensive function is high dimensional. While many previous works have focused on developing an approximative predictor to resolve these issues, this article investigates ...
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作者：Wang, Lan; Sherwood, Ben; Li, Runze
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
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作者：Rockova, Veronika; George, Edward I.
作者单位：University of Pennsylvania
摘要：Despite rapid developments in stochastic search algorithms, the practicality of Bayesian variable selection methods has continued to pose challenges. High-dimensional data are now routinely analyzed, typically with many more covariates than observations. To broaden the applicability of Bayesian variable selection for such high-dimensional linear regression contexts, we propose EMVS, a deterministic alternative to stochastic search based on an EM algorithm which exploits a conjugate mixture pri...
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作者：Matteson, David S.; James, Nicholas A.
作者单位：Cornell University; Cornell University
摘要：Change point analysis has applications in a wide variety of fields. The general problem concerns the inference of a change in distribution for a set of time-ordered observations. Sequential detection is an online version in which new data are continually arriving and are analyzed adaptively. We are concerned with the related, but distinct, offline version, in which retrospective analysis of an entire sequence is performed. For a set of multivariate observations of arbitrary dimension, we consi...
