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作者:Guo, Jia; Zhou, Bu; Zhang, Jin-Ting
作者单位:Zhejiang University of Technology; University of Melbourne; University of Melbourne; Zhejiang Gongshang University; National University of Singapore
摘要:In this article, we propose two new tests for the equality of the covariance functions of several functional populations, namely, a quasi-GPF test and a quasi-F-max test whose test statistics are obtained via globalizing a pointwise quasi-F-test statistic with integration and taking its supremum over some time interval of interest, respectively. Unlike several existing tests, they are scale-invariant in the sense that their test statistics will not change if we multiply each of the observed fu...
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作者:Windmeijer, Frank; Farbmacher, Helmut; Davies, Neil; Smith, George Davey
作者单位:University of Bristol; Max Planck Society; University of Bristol
摘要:We investigate the behavior of the Lasso for selecting invalid instruments in linear instrumental variables models for estimating causal effects of exposures on outcomes, as proposed recently by Kang et al. Invalid instruments are such that they fail the exclusion restriction and enter the model as explanatory variables. We show that for this setup, the Lasso may not consistently select the invalid instruments if these are relatively strong. We propose a median estimator that is consistent whe...
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作者:Benjamini, Yuval; Taylor, Jonathan; Irizarry, Rafael A.
作者单位:Hebrew University of Jerusalem; Stanford University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University
摘要:Scientists use high-dimensional measurement assays to detect and prioritize regions of strong signal in spatially organized domain. Examples include finding methylation-enriched genomic regions using microarrays, and active cortical areas using brain-imaging. The most common procedure for detecting potential regions is to group neighboring sites where the signal passed a threshold. However, one needs to account for the selection bias induced by this procedure to avoid diminishing effects when ...
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作者:Gao, Fei; Zeng, Donglin; Couper, David; Lin, D. Y.
作者单位:University of North Carolina; University of North Carolina Chapel Hill
摘要:Health sciences research often involves both right- and interval-censored events because the occurrence of a symptomatic disease can only be observed up to the end of follow-up, while the occurrence of an asymptomatic disease can only be detected through periodic examinations. We formulate the effects of potentially time-dependent covariates on the joint distribution of multiple right- and interval-censored events through semiparametric proportional hazards models with random effects that capt...
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作者:Dryden, Ian L.; Preston, Simon P.; Severn, Katie E.
作者单位:University of Nottingham
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作者:Qian, Wei; Ding, Shanshan; Cook, R. Dennis
作者单位:University of Delaware; University of Minnesota System; University of Minnesota Twin Cities
摘要:Sufficient dimension reduction (SDR) is known to be a powerful tool for achieving data reduction and data visualization in regression and classification problems. In this work, we study ultrahigh-dimensional SDR problems and propose solutions under a unified minimum discrepancy approach with regularization. When p grows exponentially with n, consistency results in both central subspace estimation and variable selection are established simultaneously for important SDR methods, including sliced ...
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作者:Li, Furong; Sang, Huiyan
作者单位:Ocean University of China; Texas A&M University System; Texas A&M University College Station
摘要:Spatial regression models have been widely used to describe the relationship between a response variable and some explanatory variables over a region of interest, taking into account the spatial dependence of the observations. In many applications, relationships between response variables and covariates are expected to exhibit complex spatial patterns. We propose a new approach, referred to as spatially clustered coefficient (SCC) regression, to detect spatially clustered patterns in the regre...
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作者:Arias-Castro, Ery; Pateiro-Lopez, Beatriz; Rodriguez-Casal, Alberto
作者单位:University of California System; University of California San Diego; Universidade de Santiago de Compostela
摘要:We consider the problem of estimating the volume of a compact domain in a Euclidean space based on a uniform sample from the domain. We assume that the domain has a boundary with positive reach. We propose a data-splitting approach to correct the bias of the plug-in estimator based on the sample alpha-convex hull. We show that this simple estimator achieves a minimax lower bound that we derive. Some numerical experiments corroborate our theoretical findings. Supplementary materials for this ar...
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作者:Marron, J. S.
作者单位:University of North Carolina; University of North Carolina Chapel Hill
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作者:Benkeser, David; Gilbert, Peter B.; Carone, Marco
作者单位:Emory University; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle
摘要:When available, vaccines are an effective means of disease prevention. Unfortunately, efficacious vaccines have not yet been developed for several major infectious diseases, including HIV and malaria. Vaccine sieve analysis studies whether and how the efficacy of a vaccine varies with the genetics of the pathogen of interest, which can guide subsequent vaccine development and deployment. In sieve analyses, the effect of the vaccine on the cumulative incidence corresponding to each of several p...