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作者：Camerlenghi, Federico; Dumitrascu, Bianca; Ferrari, Federico; Engelhardt, Barbara E.; Favaro, Stefano
作者单位：University of Milano-Bicocca; Institute for Advanced Study - USA; Duke University; Princeton University; University of Turin
摘要：The problem of maximizing cell type discovery under budget constraints is a fundamental challenge for the collection and analysis of single-cell RNA-sequencing (scRNA-seq) data. In this paper we introduce a simple, computationally efficient and scalable Bayesian nonparametric sequential approach to optimize the budget allocation when designing a large-scale experiment for the collection of scRNA-seq data for the purpose of, but not limited to, creating cell atlases. Our approach relies on the ...
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作者：Soltoft-Jensen, Aleksander; Heide-Jorgensen, Mads Peter; Ditlevsen, Susanne
作者单位：University of Copenhagen; Greenland Institute of Natural Resources
摘要：Obtaining an adequate description of the behaviour of narwhals in a pristine environment is important to understand natural behaviour as well as providing the means to determine potential changes in behaviour directly or indirectly caused by human activity. Based on Acousonde (TM) data from five narwhals in Scoresby Sound, this paper aims at modelling buzzing and calling rates of East Greenland narwhals as functions of time, space and, possibly, autoregressive memory. Both buzzing and calling ...
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作者：MacDonald, Iain L.
作者单位：University of Cape Town
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作者：Reich, Brian J.; Guan, Yawen; Fourches, Denis; Warren, Joshua L.; Sarnat, Stefanie E.; Chang, Howard H.
作者单位：North Carolina State University; University of Nebraska System; University of Nebraska Lincoln; North Carolina State University; Yale University; Emory University; Emory University
摘要：Humans are concurrently exposed to chemically, structurally and toxicologically diverse chemicals. A critical challenge for environmental epidemiology is to quantify the risk of adverse health outcomes resulting from exposures to such chemical mixtures and to identify which mixture constituents may be driving etiologic associations. A variety of statistical methods have been proposed to address these critical research questions. However, they generally rely solely on measured exposure and heal...
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作者：Banerjee, Trambak; Bhattacharya, Bhaswar B.; Mukherjee, Gourab
作者单位：University of Kansas; University of Pennsylvania; University of Southern California
摘要：An important problem in contemporary immunology studies based on single-cell protein expression data is to determine whether cellular expressions are remodeled postinfection by a pathogen. One natural approach for detecting such changes is to use nonparametric two-sample statistical tests. However, in single-cell studies direct application of these tests is often inadequate, because single-cell level expression data from processed uninfected populations often contain attributes of several late...
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作者：MacDonald, Iain L.
作者单位：University of Cape Town
摘要：The problem of fitting a folded normal distribution by maximum likelihood has been described as 'not straightforward', and alternatives such as EM proposed. We suggest here that it is in fact straightforward to fit such a distribution by direct numerical maximization of the likelihood. We demonstrate this in an example. The relevant R code is included.
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作者：Schliep, Erin M.; Collins, Sarah M.; Rojas-Salazar, Shirley; Lottig, Noah R.; Stanley, Emily H.
作者单位：University of Missouri System; University of Missouri Columbia; University of Wyoming; University of Wisconsin System; University of Wisconsin Madison
摘要：Concentrations of nitrogen provide a critical metric for understanding ecosystem function and water quality in lakes. However, varying approaches for quantifying nitrogen concentrations may bias the comparison of water quality across lakes and regions. Different measurements of total nitrogen exist based on its composition (e.g., organic versus inorganic, dissolved versus particulate), which we refer to as nitrogen species. Fortunately, measurements of multiple nitrogen species are often colle...
