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作者：Whiteman, Andrew S.; Bartsch, Andreas J.; Kang, Jian; Johnson, Timothy D.
作者单位：University of Michigan System; University of Michigan; Ruprecht Karls University Heidelberg
摘要：Neuroradiologists and neurosurgeons increasingly opt to use functional magnetic resonance imaging (fMRI) to map functionally relevant brain re-gions for noninvasive presurgical planning and intraoperative neuronaviga-tion. This application requires a high degree of spatial accuracy, but the fMRI signal-to-noise ratio (SNR) decreases as spatial resolution increases. In prac-tice, fMRI scans can be collected at multiple spatial resolutions, and it is of interest to make more accurate inference o...
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作者：Tang, Chen; Shang, Han Lin; Yang, Yanrong
作者单位：Australian National University; Macquarie University
摘要：Modeling and forecasting homogeneous age-specific mortality rates of multiple countries could lead to improvements in long-term forecasting. Data fed into joint models are often grouped according to nominal attributes, such as geographic regions, ethnic groups, and socioeconomic status, which may still contain heterogeneity and deteriorate the forecast results. Our paper proposes a novel clustering technique to pursue homogeneity among multiple functional time series, based on functional panel...
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作者：Farcomeni, Alession
作者单位：University of Rome Tor Vergata
摘要：We estimate the number of migrants and refugees that died while trying to enter the European Union, during a period of 25 years. Only a subset of at-tempts with at least one casualty are reported by at least one media source. In order to obtain the estimate, we propose a regression-extrapolation approach, for joint estimation of population size (here, the number of deadly individual or group attempts) and the sum of an accompanying trait (here, the number of deaths) over the population. The tr...
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作者：Baugh, Samuel; Mckinnon, Karen
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：The accurate quantification of changes in the heat content of the world's oceans is crucial for our understanding of the effects of increasing green-house gas concentrations. The Argo program, consisting of Lagrangian floats that measure vertical temperature profiles throughout the global ocean, has provided a wealth of data from which to estimate ocean heat content. How-ever, creating a globally consistent statistical model for ocean heat content remains challenging due to the need for a glob...
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作者：Legramanti, Sirio; Rigon, Tommaso; Durante, Daniele; Dunson, David B.
作者单位：Bocconi University; Bocconi University; University of Milano-Bicocca; Duke University
摘要：Reliably learning group structures among nodes in network data is challenging in several applications. We are particularly motivated by studying covert networks that encode relationships among criminals. These data are subject to measurement errors, and exhibit a complex combination of an unknown number of core-periphery, assortative and disassortative structures that may unveil key architectures of the criminal organization. The coexistence of these noisy block patterns limits the reliability...
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作者：Benedetti, Marco H.; Berrocal, Veronica J.; Little, Roderick J.
作者单位：University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Research Institute at Nationwide Children's Hospital; University of Michigan System; University of Michigan
摘要：Understanding the effects of social determinants of health on health out-comes requires data on characteristics of the neighborhoods in which sub-jects live. However, estimates of these characteristics are often aggregated over space and time in a fashion that diminishes their utility. Take, for exam-ple, estimates from the American Community Survey (ACS), a multiyear na-tionwide survey administered by the U.S. Census Bureau: estimates for small municipal areas are aggregated over 5-year perio...
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作者：Jiang, Lingjing; Elrod, Chris; Kim, Jane J.; Swafford, Austin D.; Knight, Rob; Thompson, Wesley K.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Microbiome researchers often need to model the temporal dynamics of multiple complex, nonlinear outcome trajectories simultaneously. This motivates our development of multivariate Sparse Functional Principal Components Analysis (mSFPCA), extending existing SFPCA methods to simultaneously characterize multiple temporal trajectories and their interrelationships. As with existing SFPCA methods, the mSFPCA algorithm characterizes each trajectory as a smooth mean plus a weighted combination of the ...
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作者：Saha, Abhisek; HA, Min Jin; Acharyya, Satwik; Baladandayuthapani, Veerabhadran
作者单位：National Institutes of Health (NIH) - USA; Yonsei University; Yonsei University Health System; University of Michigan System; University of Michigan
摘要：The development and clinical implementation of evidence-based preci-sion medicine strategies has become a realistic possibility, primarily due to the rapid accumulation of large-scale genomics and pharmacological data from diverse model systems: patients, cell lines and drug perturbation studies. We introduce a novel Bayesian modeling framework called the individualized theRapeutic index (iRx) model to integrate high-throughput pharmacoge-nomic data across model systems. Our iRx model achieves...
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作者：Sun, Yifei; He, Xuming; Hu, Jianhua
作者单位：Columbia University; University of Michigan System; University of Michigan
摘要：Late-stage clinical trials have been conducted primarily to establish the efficacy of a new treatment in an intended population. A corollary of population heterogeneity in clinical trials is that a treatment might be effective for one or more subgroups, rather than for the whole population of interest. As an example, the phase III clinical trial of panitumumab in metastatic colorectal cancer patients failed to demonstrate its efficacy in the overall population, but a subgroup associated with t...
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作者：Casa, Alessandro; O'callaghan, Tom f.; Murphy, Thomas brendan
作者单位：University College Dublin; University College Cork
摘要：In recent years, within the dairy sector, animal diet and management practices have been receiving increased attention, in particular, examining the impact of pasture-based feeding strategies on the composition and quality of milk and dairy products in line with the prevalence of premium grass-fed dairy products appearing on market shelves. To date, methods to thoroughly investigate the more relevant differences induced by the diet on milk chemi-cal features are limited; enhanced statistical t...
