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作者：Chen, Qiushi; Ayer, Turgay; Chhatwal, Jagpreet
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University System of Georgia; Georgia Institute of Technology; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fastest-growing cause of cancer-related deaths in the United States. Most HCC cases are attributed to chronic hepatitis C virus infection, which affects nearly 3 million Americans and 100 million people globally. Although surveillance for HCC m hepatitis C patients can improve survival, the optimal surveillance policies remain unknown. In this study, we develop a mixed-integer programming (MlP)-based framework to sy...
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作者：Xu, Zhou; Lee, Chung-Yee
作者单位：Hong Kong Polytechnic University; Hong Kong University of Science & Technology
摘要：We study a continuous berth allocation problem, where incoming vessels need to be assigned a mooring time as well as a berth location on a quay. It is a crucial element in port planning to achieve quick turnaround time for vessels. To solve this problem, many solution methods have been developed in the literature. However, gaps between the best-known lower and upper bounds on its optimal solutions are far from close. In this paper, we propose new and more effective solution methods for this im...
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作者：Schlapp, Jochen; Fleischmann, Moritz
作者单位：University of Mannheim
摘要：The presence of customer substitution poses substantial challenges to a firm's inventory management, particularly so when the firm has to manage a multiproduct portfolio with capacity restrictions. In this paper, we derive the optimal inventory policy for a capacity-constrained firm selling multiple partially substitutable products over a finite season in a market with stockout-based customer substitution. We also establish the sensitivity of the optimal policy with respect to changes in capac...
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作者：McCardle, Kevin F.; Tsetlin, Ilia; Winkler, Robert L.
作者单位：University of California System; University of California Los Angeles; INSEAD Business School; Duke University
摘要：We investigate the cost of the opportunity delayed by working on one project with uncertain success rather than searching for a new project. We answer this question: How long should a firm work on a research project with uncertain success before abandoning it if the only alternative is to search for a new project to work on? Rather than treating the opportunity as an exogenous alternative, this approach endogenizes the opportunity value and the attendant cost of its delay. We consider cases wi...
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作者：Anari, Nima; Goel, Gagan; Nikzad, Afshin
作者单位：Stanford University
摘要：We consider a simple and well-studied model for procurement problems and solve it to optimality. A buyer with a fixed budget wants to procure, from a set of available workers, a budget feasible subset that maximizes her utility: Any worker has a private reservation price and provides a publicly known utility to the buyer in case of being procured. The buyer's utility function is additive over items. The goal is designing a direct revelation mechanism that solicits workers' reservation prices a...
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作者：Strinka, Zohar M. A.; Romeijn, H. Edwin
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：We study a class of problems with both binary selection decisions and associated continuous choices that result in stochastic rewards and costs. The rewards are received based on the decision maker's selection, and the costs depend both on the decisions and realizations of the stochastic variables. We consider a family of risk-based objective functions that contains the traditional risk-neutral expected-value objective as a special case. A combination of rounding and sample average approximati...
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作者：Aswani, Anil; Shen, Zuo-Jun (Max); Siddiq, Auyon
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Los Angeles
摘要：Inverse optimization refers to the inference of unknown parameters of an optimization problem based on knowledge of its optimal solutions. This paper considers inverse optimization in the setting where measurements of the optimal solutions of a convex optimization problem are corrupted by noise. We first provide a formulation for inverse optimization and prove it to be NP-hard. In contrast to existing methods, we show that the parameter estimates produced by our formulation are statistically c...
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作者：Simsek, A. Serdar; Topaloglu, Huseyin
作者单位：University of Texas System; University of Texas Dallas
摘要：We develop an expectation-maximization algorithm to estimate the parameters of the Markov chain choice model. In this choice model, a customer arrives into the system to purchase a certain product. If this product is available for purchase, then the customer purchases it. Otherwise, the customer transitions between the products according to a transition probability matrix until she reaches an available one and purchases this product. The parameters of the Markov chain choice model are the prob...
