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作者：Fattahi, Ali; Dasu, Sriram; Ahmadi, Reza
作者单位：University of California System; University of California Los Angeles; University of Southern California
摘要：Auto manufacturers produce a very large number of feasible configurations that make it impossible to forecast the demand of individual configurations. What the companies do forecast is the penetration rate of each option, which is the percentage of cars that include that option. The current forecasting approach ignores rules for selecting options, and as a result, forecast penetration rates are frequently infeasible, which results in excess inventories, shortages, and customer dissatisfaction....
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作者：Kerstens, Kristiaan; Sadeghi, Jafar; Van de Woestyne, Ignace
作者单位：IESEG School of Management; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Kharazmi University; KU Leuven
摘要：The output-oriented plant capacity notion, which has been around for more than two decades, has been empirically applied mainly in the fishery and the hospital sectors. Since its introduction to the literature, a specified problem is that this notion may not be attainable, in that it presupposes potentially unlimited numbers of variable inputs to determine the maximum number of outputs available. However, this lack of attainability has not been explored previously. This paper fills this void b...
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作者：Bertsimas, Dimitris; Korolko, Nikita; Weinstein, Alexander M.
作者单位：Massachusetts Institute of Technology (MIT)
摘要：The decision of how to allocate subjects to treatment groups is of great importance in experimental clinical trials for novel investigational drugs, a multibillion-dollar industry. Statistical power, the ability of an experiment to detect a positive treatment effect when one exists, depends in part on the similarity of the groups in terms of measurable covariates that affect the treatment response. We present a novel algorithm for online allocation that leverages robust mixed-integer optimizat...
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作者：Alexopoulos, Christos; Goldsman, David; Mokashi, Anup C.; Tien, Kal-Wen; Wilson, James R.
作者单位：University System of Georgia; Georgia Institute of Technology; SAS Institute Inc; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; North Carolina State University
摘要：Sequest is an automated sequential simulation-analysis procedure designed to provide improved point and confidence-interval (CI) estimators for a designated steady-state quantile by the use of batching and sectioning. The procedure incorporates techniques to do the following: (i) reduce the absolute bias of the sectioning-based point estimator caused by atypical simulation initialization or an inadequate sample size, (ii) adjust the batching-based CI half-length to compensate for correlation o...
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作者：Afeche, Philipp; Baron, Opher; Milner, Joseph; Roet-Green, Ricky
作者单位：University of Toronto; University of Rochester
摘要：We consider the pricing/lead-time menu design problem for a monopoly service in which time-sensitive customers have demand on multiple occasions. Customers differ in their demand rates and marginal values (per use). We assume that customers queue for a finite-capacity service under a general pricing structure. Customers choose a plan from the menu to maximize their expected utility. We compare two models: one in which the demand rate is the private information of the customers, and another in ...
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作者：Ashlagi, Itai; Burq, Maximilien; Jaillet, Patrick; Manshadi, Vahideh
作者单位：Stanford University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Yale University
摘要：We study dynamic matching in an infinite-horizon stochastic market. Although all agents are potentially compatible with each other, some are hard to match and others are easy to match. Agents prefer to be matched as soon as possible, and matches are formed either bilaterally or indirectly through chains. We adopt an asymptotic approach and compute tight bounds on the limit of waiting time of agents under myopic policies that differ in matching technology and prioritization. We find that when h...
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作者：Feng, Youyi; Xu, Jianjun; Zheng, Shaohui
作者单位：Sichuan University; Dongbei University of Finance & Economics; Dongbei University of Finance & Economics; Hong Kong University of Science & Technology
摘要：We consider a periodic-review inventory system of two products with positive replenishment lead times, assuming that downward substitution is allowed and that replenishment is capped. We aim to characterize the structures of the optimal policies for product replenishment and substitution that minimize the expected total discounted cost over a finite horizon. With a Markovian decision programming formulation and an appropriate relaxation of constraints on the substitution quantity, we show that...
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作者：Davarnia, Daniel; Richard, Jean-Philippe P.; Icyuz-Ay, Ece; Taslimi, Bijan
作者单位：Iowa State University; Iowa State University; University of Minnesota System; University of Minnesota Twin Cities; State University System of Florida; University of Florida
摘要：We study network models where flows cannot be split or merged when passing through certain nodes (i.e., for such nodes, each incoming arc flow must be matched to an outgoing arc flow of identical value). This requirement, which we call no-split no-merge (NSNM), appears in railroad applications in which train compositions can only be modified at yards where necessary equipment is available. This combinatorial requirement is crucial when formulating problems occurring in the unit train business....
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作者：Wang, Dongyang; Muthuraman, Kumar; Morrice, Douglas
作者单位：University of Texas System; University of Texas Austin
摘要：Current healthcare reforms advocate significantly to improve the coordination of services around a patient-centric model. With most patient care delivered through outpatient services, the need to coordinate scheduling between different services in a hospital or colocated clinics becomes central to successful reform. Currently, outpatient services require independent appointment decisions, and the coordination is left to the patient. This approach causes several inefficiencies, including an inc...
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作者：Chehrazi, Naveed; Cipriano, Lauren E.; Enns, Eva A.
作者单位：University of Texas System; University of Texas Austin; Western University (University of Western Ontario); University of Minnesota System; University of Minnesota Twin Cities
摘要：Antimicrobial resistance is a significant public health threat. In the United States alone, two million people are infected, and 23,000 die each year from antibiotic-resistant bacterial infections. In many cases, infections are resistant to all but a few remaining drugs. We examine the case in which a single drug remains and solve for the optimal treatment policy for a susceptible-infected-susceptible infectious disease model, incorporating the effects of drug resistance. The problem is formul...
