Evolution of drug-resistant ovarian-cancer clones tracked in patients
成果类型：
News Item; Early Access
署名作者：
Williams, Marc J.; Shah, Sohrab P.
署名单位：
Memorial Sloan Kettering Cancer Center
刊物名称：
NATURE
ISSN/ISSBN：
0028-0836; 1476-4687
DOI：
10.1038/d41586-025-03163-9
发表日期：
2025-10-01
关键词：
摘要：
After an initial treatment response, most ovarian cancers recur because of drug-resistant cell populations. Blood-based tracking, used to monitor clonal evolution in 18 patients, shows that drug-resistant clones are already present at diagnosis, expand during therapy and contain distinctive genomic alterations that have potential therapeutic relevance.
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