The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

• 成果类型: Review
• 署名作者: Sebe-Pedros, Arnau; Tanay, Amos; Lawniczak, Mara K. N.; Arendt, Detlev; Aerts, Stein; Archibald, John; Arnone, Maria Ina; Blaxter, Mark; Cleves, Phillip; Coelho, Susana M.; Dias, Mafalda; Dunn, Casey; Elek, Anamaria; Frazer, Jonathan; Gabaldon, Toni; Gillis, Jesse; Grau-Bove, Xavier; Guigo, Roderic; Hobert, Oliver; Huerta-Cepas, Jaime; Irimia, Manuel; Klein, Allon; Lewin, Harris; Lowe, Christopher J.; Marlow, Heather; Musser, Jacob M.; Nagy, Laszlo G.; Najle, Sebastian R.; Pachter, Lior; Paez, Sadye; Papatheodorou, Irene; Passalacqua, Michael J.; Rajewsky, Nikolaus; Rhee, Seung Y.; Richards, Thomas A.; Sauka-Spengler, Tatjana; Saunders, Lauren M.; Seuntjens, Eve; Solana, Jordi; Song, Yuyao; Technau, Ulrich; Wang, Bo; Biodiversity Cell Atlas meeting participants
• 署名单位: Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); Wellcome Trust Sanger Institute; Pompeu Fabra University; ICREA; Weizmann Institute of Science; Weizmann Institute of Science; European Molecular Biology Laboratory (EMBL); Flanders Institute for Biotechnology (VIB); KU Leuven; Dalhousie University; Stazione Zoologica Anton Dohrn; Carnegie Institution for Science; Johns Hopkins University; Yale University; Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Toronto; University of Toronto; Columbia University; Howard Hughes Medical Institute; Universidad Politecnica de Madrid; Harvard University; Harvard Medical School; Arizona State University; Arizona State University-Tempe; University of California System; University of California Davis; Stanford University; University of Chicago; Yale University; Yale University; HUN-REN; HUN-REN Biological Research Center; California Institute of Technology; California Institute of Technology; Rockefeller University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Earlham Institute; University of East Anglia; Cold Spring Harbor Laboratory; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; German Centre for Cardiovascular Research; Michigan State University; Michigan State University; Michigan State University; Michigan State University; University of Oxford; Stowers Institute for Medical Research; University of Oxford; Ruprecht Karls University Heidelberg; KU Leuven; University of Exeter; University of Exeter; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of Vienna; Stanford University
• 刊物名称: NATURE
• ISSN/ISSBN: 0028-0836; 1476-4687
• DOI: 10.1038/s41586-025-09312-4
• 发表日期: 2025-09-25
• 页码: 877-885
• 关键词: gene-expression; EVOLUTION; diversity; origin; sequence; genome

摘要

Cell types are fundamental functional units that can be traced across the tree of life. Rapid advances in single-cell technologies, coupled with the phylogenetic expansion in genome sequencing, present opportunities for the molecular characterization of cells across a broad range of organisms. Despite these developments, our understanding of eukaryotic cell diversity remains limited and we are far from decoding this diversity from genome sequences. Here we introduce the Biodiversity Cell Atlas initiative, which aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life. This community effort will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species. The Biodiversity Cell Atlas aspires to deepen our understanding of the evolution and diversity of life at the cellular level, encompassing gene regulatory programs, differentiation trajectories, cell-type-specific molecular profiles and inter-organismal interactions.