A bacterial nutrition strategy for plant disease control
成果类型：
Article
署名作者：
Wang, Shanzhi; Zhu, Lisong; Tian, Meng; Wu, Wenyi; Hu, Xu; Li, Xuan; Wang, Jiyang; Zhu, Ying; Xu, Jiaqing; Mou, Baohui; Yang, Jiyun; Cui, Fuhao; Li, Dayong; Cheng, Jie; Liu, Zhilong; Wang, Ming-An; Qi, Linlu; Jin, Weiwei; Luo, Zhao-Qing; Zhou, Pei; Lee, Yong-Hwan; Staskawicz, Brian; He, Sheng Yang; Sun, Wenxian
署名单位：
China Agricultural University; Southwest University - China; Jilin Agricultural University; Duke University; Duke University; China Agricultural University; China Agricultural University; China Agricultural University; Jilin University; Seoul National University (SNU); University of California System; University of California Berkeley; University of California System; University of California Berkeley; Duke University; Howard Hughes Medical Institute
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-8075; 1095-9203
DOI：
10.1126/science.ady8325
发表日期：
2025-12-18
页码：
1299-1304
关键词：
AGROCINOPINE-A
XANTHOMONAS
spectroscopy
摘要：
Xanthomonas spp. cause serious diseases in more than 400 plant species. The conserved AvrBs2 family effectors are among the most important virulence factors in xanthomonads, but how AvrBs2 promotes infection remains elusive. We found that AvrBs2 is a glycerophosphodiesterase-derived synthetase that catalyzes uridine 5 '-diphosphate-alpha-d-galactose into a sugar phosphodiester, bis-(1,6)-cyclic dimeric alpha-d-galactose-phosphate, which is referred to as xanthosan. Xanthosan is synthesized by AvrBs2 in host cells and released into apoplastic spaces. Xanthomonas bacteria uptake xanthosan through the XanT transporter and hydrolyze it through the XanP phosphodiesterase for nutrition. AvrBs2, XanT, and XanP form a xanthosan generation-uptake-utilization system to provide a dedicated nutritional strategy to feed xanthomonads. Furthermore, elucidation of the AvrBs2-XanT-XanP virulence mechanism inspired us to develop an anti-nutrition strategy that should be applicable to control a wide variety of Xanthomonas diseases.
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