Inference on covariance structure in high-dimensional multi-view data

• 成果类型: Article
• 署名作者: Mauri, L.; Dunson, D. B.
• 署名单位: Duke University
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444; 1464-3510
• DOI: 10.1093/biomet/asag038
• 发表日期: 2026
• 页码: asag038
• 关键词: Factor analysis; High-dimensional Data; latent variable model; Multi-omics; Multi-view; Scalable Bayesian computation; Singular value decomposition; Matrix Factorization; methylation; expression; cancer; joint

摘要

This article focuses on covariance estimation for multi-view data. Popular approaches rely on factor-analytic decompositions with shared and view-specific latent factors. Posterior computation is conducted via expensive and brittle Markov chain Monte Carlo sampling or variational approximations that underestimate uncertainty and lack theoretical guarantees. Our proposed methodology employs spectral decompositions to estimate and align latent factors that are active in at least one view. Conditionally on these factors, we choose jointly conjugate prior distributions for factor loadings and residual variances. The resulting posterior is a simple product of normal-inverse gamma distributions for each variable, bypassing Markov chain Monte Carlo and facilitating posterior computation. We prove favourable increasing-dimension asymptotic properties, including posterior contraction and central limit theorems for point estimators. We show excellent performance in simulations, including accurate uncertainty quantification, and apply the methodology to integrate four high-dimensional views from a multi-omics dataset of cancer cell samples.