IMPORTANCE OF PATIENT HORIZON IN SEQUENTIAL-ANALYSIS OF BINOMIAL CLINICAL-TRIALS
成果类型：
Article
署名作者：
UPTON, GJG; LEE, RD
署名单位：
University of Essex
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.2307/2335628
发表日期：
1976
页码：
335342
关键词：
摘要：
The sequential allocation of treatments by an experimenter is considered in the context of the patient horizon. The importance of taking into account the whole of the patient population in designing the trial is illustrated for play-the-winner allocation and vector-at-a-time allocation, both with success lead termination. The optimal scheme minimizes the total number of patients who receive the poorer treatment. The difference between the 2 allocation schemes is small compared with the differences which result from incorrect estimation of the patient horizon, or from the usual procedure of ignoring the patient horizon and selecting an arbitrary significance level. Proposals are made concerning the operation of the termination rule in the absence of complete information about the patient horizon and other parameters.