ANALYSIS OF SEQUENTIAL CLINICAL-TRIALS
成果类型：
Article
署名作者：
WHITEHEAD, J; JONES, D
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
发表日期：
1979
页码：
443452
关键词：
摘要：
The conduct of a sequential clinical trial is considered in 2 distinct stages, the planning of the trial and the analysis of the results. Tests based on straight line stopping boundaries are considered. The planning stage is described in terms of existing theory and results are presented which allow significance levels to be quoted and interval estimates to be given at the analysis stage. Tables for use in the calculation of significance levels are included. The accuracy of large sample results is assessed by computer simulation.