SEQUENTIAL ESTIMATION IN 2-ARMED EXPONENTIAL CLINICAL-TRIALS
成果类型：
Article
署名作者：
HAYRE, LS; TURNBULL, BW
署名单位：
Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Cornell University
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.2307/2335586
发表日期：
1981
页码：
411416
关键词：
摘要：
Asymptotically optimal sequential procedures are developed for point and interval estimation of the difference and ratio of the means of 2 experimental populations. This is done in a clinical trial setting in which the responses are exponentially distributed survival times and are subject to censoring. The usual situation in which observations are immediate is treated as a special case. Some simulation results are given for moderate sample sizes [i.e., patients, treatments and death].