ASYMMETRIC GROUP SEQUENTIAL BOUNDARIES FOR MONITORING CLINICAL-TRIALS
成果类型：
Note
署名作者：
DEMETS, DL; WARE, JH
署名单位：
Harvard University; Harvard T.H. Chan School of Public Health
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
发表日期：
1982
页码：
661663
关键词：
摘要：
A group sequential method is proposed for the periodic analysis of accumulating data in clinical trials which are essentially 1-sided as in treatment-placebo studies. The proposed boundaries retain the early stopping properties of the procedure described previously by DeMets and Ware (1980) when treatment appears to be ineffective or harmful but incorporate the more stringent requirement of the model proposed by O''Brien and Fleming (1979) for early rejection of the null hypothesis in favor of treatment.