DISCRETE SEQUENTIAL BOUNDARIES FOR CLINICAL-TRIALS
成果类型：
Article
署名作者：
LAN, KKG; DEMETS, DL
署名单位：
University of Wisconsin System; University of Wisconsin Madison
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.2307/2336502
发表日期：
1983
页码：
659663
关键词：
摘要：
Pocock (1977), O''Brien and Fleming (1979) and Slud and Wei (1982) have proposed different methods to construct discrete sequential boundaries for clinical trials. These methods require that the total number of decision times be specified in advance. A more flexible way to construct discrete sequential boundaries is proposed. The method is based on the choice of a function, .alpha.*(t), which characterizes the rate at which the error level .alpha. is spent. The boundary at a decision time is determined by .alpha.*(t), and by past and current decision times, but does not depend on the future decision times or the total number of decision times.