ESTIMATING THE TUMOR ONSET DISTRIBUTION IN ANIMAL CARCINOGENESIS EXPERIMENTS
成果类型：
Article
署名作者：
PORTIER, CJ
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
发表日期：
1986
页码：
371378
关键词：
摘要：
In most survival-sacrifice experiments for the detection and quantification of risks from chronic exposure to chemical agents, the onset of the condition of interest is not clinically observable. Cancer is typically such an event. In this paper, an approximate maximum likelihood method is proposed for parametric estimation of the distribution of unobservable tumour onset times in the presence of competing risks, when cause-of-death information is unavailable.