A CASE-COHORT DESIGN FOR EPIDEMIOLOGIC COHORT STUDIES AND DISEASE PREVENTION TRIALS
成果类型：
Article
署名作者：
PRENTICE, RL
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
发表日期：
1986
页码：
111
关键词：
摘要：
Suppose that a cohort of individuals is to be followed in order to relate failure rates to preceding covariate histories. A design is proposed which involves covariate data only for cases experiencing failure and for members of a randomly selected subcohort. Odds ratio and relative risk estimation procedures are presented for such a ''case-cohort'' design. A small simulation study compares case-cohort relative risk estimation procedures to full-cohort and synthetic case-control analyses. Relevance to epidemiologic cohort studies and disease prevention trials is discussed.