RECURSIVE NONPARAMETRIC TESTING FOR DOSE-RESPONSE RELATIONSHIPS SUBJECT TO DOWNTURNS AT HIGH-DOSES
成果类型：
Article
署名作者：
SIMPSON, DG; MARGOLIN, BH
署名单位：
National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
发表日期：
1986
页码：
589596
关键词：
摘要：
A general recursive strategy is introduced to test nonparametrically for an increasing dose-response relationship when a downturn in response at high doses is possible. A specific implementation involving a test of Jonckheere (1954) and Terpstra (1952) is considered, and it''s size and power properties are investigated via Monte Carlo methods. Data from mutation research illustrate the phenomenon of concern.