LEAST-SQUARES ESTIMATION OF THE CONTACT RATE IN MODELS FOR THE SPREAD OF INFECTIOUS-DISEASES
成果类型：
Article
署名作者：
HEATHCOTE, CR; NICHOLLS, DF
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.1093/biomet/77.1.161
发表日期：
1990
页码：
161168
关键词：
摘要：
The contact rate and associated contact number determine the rate of spread of an infectious disease whose population dynamics are described by a mathematical model. It is shown how to obtain least-squares estimates of the contact rate for a standard homogenous univariate model and a four-group model with different contact rates between the groups. The results of a small scale simulation are presented in the case of the four-group model. It is argued that the least-squares method provides generally acceptable estimates of contact rates for the range of parameter values likely to arise in epidemiological studies.