INTERIM ANALYSES WITH REPEATED MEASUREMENTS IN A SEQUENTIAL CLINICAL-TRIAL
成果类型：
Article
署名作者：
WEI, LJ; SU, JQ; LACHIN, JM
署名单位：
George Washington University
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.1093/biomet/77.2.359
发表日期：
1990
页码：
359364
关键词：
摘要：
In comparing two treatments, suppose that patients are available for the study sequentially. Repeated measurements of the same characteristic are collected serially over time for each study patient. Sequential procedures are proposed to monitor the trial for early evidence of treatment difference or harmful side effects based on such repeated measurements. All the methods are illustrated with a real-life example.