Modelling multivariate failure time associations in the presence of a competing risk

• 成果类型: Article
• 署名作者: Bandeen-Roche, K; Liang, KY
• 署名单位: Johns Hopkins University
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/89.2.299
• 发表日期: 2002
• 页码: 299314
• 关键词: semiparametric estimation; archimedean copulas; regression-analysis; censored-data; survival; AGE; comorbidity; disability; adjustment; frailties

摘要

There has been much research on analysing multivariate failure times, but little that has accommodated failures that arise in the presence of a competing failure process. This paper studies the problem of describing associations among times to such failures. It proposes a modified conditional hazard ratio measure of association that is tailored to competing risks data, develops frailty models and a nonparametric method for describing the proposed measure, and contrasts estimation by proposed methods with the 'standard' of treating competing risks as independently censoring failure times due to targeted causes. The methods are investigated on simulated and real data.