Semiparametric inference in observational duration-response studies, with duration possibly right-censored

• 成果类型: Article
• 署名作者: Johnson, BA; Tsiatis, AA
• 署名单位: University of North Carolina; University of North Carolina Chapel Hill; North Carolina State University
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/92.3.605
• 发表日期: 2005
• 页码: 605618
• 关键词: models

摘要

Once treatment is found to be effective in clinical studies, attention often focuses on optimum or efficacious treatment delivery. In treatment duration-response studies, the optimum treatment delivery refers to the treatment length that optimises the mean response. In many studies, the treatment length is often left to the discretion of an attending investigator or physician but may be abruptly terminated because of treatment-terminating events. Thus, a recommended treatment length often delineates a 'treatment duration policy' which prescribes that treatment be given for a specified length of time or until a treatment-terminating event occurs, whichever comes first. Estimating a functional relationship between the response and a treatment duration policy, continuously in time, is the focus of this paper.