Joint modelling of accelerated failure time and longitudinal data

• 成果类型: Article
• 署名作者: Tseng, YK; Hsieh, FS; Wang, JL
• 署名单位: University of California System; University of California Davis
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/92.3.587
• 发表日期: 2005
• 页码: 587603
• 关键词: survival

摘要

The accelerated failure time model is an attractive alternative to the Cox model when the proportionality assumption fails to capture the relationship between the survival time and longitudinal covariates. Several complications arise when the covariates are measured intermittently at different time points for different subjects, possibly with measurement errors, or measurements are not available after the failure time. Joint modelling of the failure time and longitudinal data offers a solution to such complications. We explore the joint modelling approach under the accelerated failure time assumption when covariates are assumed to follow a linear mixed effects model with measurement errors. The procedure is based on maximising the joint likelihood function with random effects treated as missing data. A Monte Carlo EM algorithm is used to estimate all the unknown parameters, including the unknown baseline hazard function. The performance of the proposed procedure is checked in simulation studies. A case study of reproductive egg-laying data for female Mediterranean fruit flies and their relationship to longevity demonstrate the effectiveness of the new procedure.