Nonparametric estimation of age-at-onset distributions from censored kin-cohort data

• 成果类型: Article
• 署名作者: Wang, Yuanjia; Clark, Lorraine N.; Marder, Karen; Rabinowitz, Daniel
• 署名单位: Columbia University; Columbia University; Columbia University; Columbia University
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/asm027
• 发表日期: 2007
• 页码: 403414
• 关键词: family-history data; parkinsons-disease; mutations; aggregation; gene; association; genotype; designs; RISK

摘要

We present a nonparametric estimator of genotype-specific age-at-onset distributions from kin-cohort data. Standard error calculations. are derived and the methodology is illustrated through an analysis of the influence of mutations of the Parkin gene on Parkinson's disease. Semiparametric efficiency considerations are briefly discussed.