Aalen additive hazards change-point model

• 成果类型: Article
• 署名作者: Martinussen, Torben; Scheike, Thomas H.
• 署名单位: University of Copenhagen; University of Copenhagen
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/asm054
• 发表日期: 2007
• 页码: 861872
• 关键词: cox regression-model; constant hazard; risk model; time; covariate; threshold; tests

摘要

We study a test comparing the full Aalen additive hazards model and the change-point model, and suggest how to estimate the parameters of the change-point model. We also study a test for no change-point effect. Both tests are provided with large sample properties and a resampling method is applied to obtain p-values. The finite-sample properties of the proposed inference procedures and estimators are assessed through a simulation study. The methods are further applied to a dataset concerning myocardial infarction.