Attributable fraction functions for censored event times

• 成果类型: Article
• 署名作者: Chen, Li; Lin, D. Y.; Zeng, Donglin
• 署名单位: University of North Carolina; University of North Carolina Chapel Hill
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/asq023
• 发表日期: 2010
• 页码: 713726
• 关键词: transformation models; RISK; estimators

摘要

Attributable fractions are commonly used to measure the impact of risk factors on disease incidence in the population. These static measures can be extended to functions of time when the time to disease occurrence or event time is of interest. The present paper deals with nonparametric and semiparametric estimation of attributable fraction functions for cohort studies with potentially censored event time data. The semiparametric models include the familiar proportional hazards model and a broad class of transformation models. The proposed estimators are shown to be consistent, asymptotically normal and asymptotically efficient. Extensive simulation studies demonstrate that the proposed methods perform well in practical situations. A cardiovascular health study is provided. Connections to causal inference are discussed.