Survival analysis without survival data: connecting length-biased and case-control data

• 成果类型: Article
• 署名作者: Chan, Kwun Chuen Gary
• 署名单位: University of Washington; University of Washington Seattle
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/ast008
• 发表日期: 2013
• 页码: 764770
• 关键词: regression-models; cox model; estimator; LIFE

摘要

We show that relative mean survival parameters of a semiparametric log-linear model can be estimated using covariate data from an incident sample and a prevalent sample, even when there is no prospective follow-up to collect any survival data. Estimation is based on an induced semiparametric density ratio model for covariates from the two samples, and it shares the same structure as for a logistic regression model for case-control data. Likelihood inference coincides with well-established methods for case-control data. We show two further related results. First, estimation of interaction parameters in a survival model can be performed using covariate information only from a prevalent sample, analogous to a case-only analysis. Furthermore, propensity score and conditional exposure effect parameters on survival can be estimated using only covariate data collected from incident and prevalent samples.