Uniformly minimum variance conditionally unbiased estimation in multi-arm multi-stage clinical trials

• 成果类型: Article
• 署名作者: Stallard, Nigel; Kimani, Peter K.
• 署名单位: University of Warwick
• 刊物名称: BIOMETRIKA
• ISSN/ISSBN: 0006-3444
• DOI: 10.1093/biomet/asy004
• 发表日期: 2018
• 页码: 495501
• 关键词: randomized controlled-trial; treatment selection; sequential designs; 2-stage

摘要

Multi-arm multi-stage clinical trials compare several experimental treatments with a control treatment, with poorly performing treatments dropped at interim analyses. This leads to inferential challenges, including the construction of unbiased treatment effect estimators. A number of estimators which are unbiased conditional on treatment selection have been proposed, but are specific to certain selection rules, may ignore the comparison to the control and are not all minimum variance. We obtain estimators for treatment effects compared to the control that are uniformly minimum variance unbiased conditional on selection with any specified rule or stopping for futility.