THE UP-AND-DOWN METHOD WITH SMALL SAMPLES
成果类型：
Article
署名作者：
BROWNLEE, KA; HODGES, JL; ROSENBLATT, M
刊物名称：
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
ISSN/ISSBN：
0162-1459
DOI：
10.2307/2281287
发表日期：
1953
页码：
262-277
关键词：
摘要：
From new information concerning the behavior of the up-and-down method with small samples, the authors conclude that in many expts. it is superior to the probit method forestimating an L.D.50. Since animals must be tested sequentially or at best in sequential series, the up-and-down expt. will run from 2 to 5 times as long as a probit expt. In most other respects it is superior to the probit method. For estimates of approx. equal accuracy, the up-and-down method (as opposed to the probit method) (1) usually requires less than half the number of animals, (2) in sequential testing provides an estimate of guaranteed accuracy, (3) has known small sample characteristics, (4) involves relatively little arithmetic labor, and (5) guarantees the existence of the estimate. Further advantages accrue in expts. which are designed to compare 2 or more treatments or drugs.