Modeling spatial variation in leukemia survival data

• 成果类型: Article
• 署名作者: Henderson, R; Shimakura, S; Gorst, D
• 署名单位: Lancaster University; Universidade Federal do Parana
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1198/016214502388618753
• 发表日期: 2002
• 页码: 965-972
• 关键词: infinite-divisibility; frailty

摘要

In this article we combine ideas from spatial statistics with lifetime data analysis techniques to investigate possible spatial variation in survival of adult acute myeloid leukemia patients in northwest England. Exploratory analysis suggests both clinically and statistically significant variation in survival rates across the region. A multivariate gamma frailty model incorporating spatial dependence is proposed and applied, with results confirming the dependence of hazard on location.