Nonparametric Signal Extraction and Measurement Error in the Analysis of Electroencephalographic Activity During Sleep

• 成果类型: Article
• 署名作者: Crainiceanu, Ciprian M.; Caffo, Brian S.; Di, Chong-Zhi; Punjabi, Naresh M.
• 署名单位: Johns Hopkins University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1198/jasa.2009.0020
• 发表日期: 2009
• 页码: 541-555
• 关键词: heart health; cardiovascular-disease; simulation-extrapolation; daytime sleepiness; duration; apnea; eeg; deprivation; performance; mortality

摘要

We introduce methods for signal and associated variability estimation based on hierarchical nonparametric smoothing with application to the Sleep Heart Health Study (SHHS). SHHS is the largest electroencephalographic (EEG) collection of sleep-related data, which contains, at each visit, two quasi-continuous EEG signals for each subject. The signal features extracted from EEG data are then used in second level analyses to investigate the relation between health, behavioral, or biometric outcomes and sleep. Using subject specific signals estimated with known variability in a second level regression becomes a nonstandard measurement error problem. We propose and implement methods that take into account cross-sectional and longitudinal measurement error. The research presented here forms the basis for EEG signal processing for the SHHS.