Finding Common Modules in a Time-Varying Network with Application to the Drosophila Melanogaster Gene Regulation Network

• 成果类型: Article
• 署名作者: Zhang, Jingfei; Cao, Jiguo
• 署名单位: University of Miami; Simon Fraser University
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1080/01621459.2016.1260465
• 发表日期: 2017
• 页码: 994-1008
• 关键词: fast community detection; expression; identification; multiscale; models

摘要

Finding functional modules in gene regulation networks is an important task in systems biology. Many methods have been proposed for finding communities in static networks; however, the application of such methods is limited due to the dynamic nature of gene regulation networks. In this article, we first propose a statistical framework for detecting common modules in the Drosophila melanogaster time-varying gene regulation network. We then develop both a significance test and a robustness test for the identified modular structure. We apply an enrichment analysis to our community findings, which reveals interesting results. Moreover, we investigate the consistency property of our proposed method under a time-varying stochastic block model framework with a temporal correlation structure. Although we focus on gene regulation networks in our work, our method is general and can be applied to other time-varying networks. Supplementary materials for this article are available online.