Inter-Subject Analysis: A Partial Gaussian Graphical Model Approach

• 成果类型: Article
• 署名作者: Ma, Cong; Lu, Junwei; Liu, Han
• 署名单位: Princeton University; Harvard University; Harvard T.H. Chan School of Public Health; Northwestern University; Northwestern University
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1080/01621459.2020.1841645
• 发表日期: 2021
• 页码: 746-755
• 关键词: Covariance Estimation; confidence-intervals; SPARSE; selection; connectivity

摘要

Different from traditional intra-subject analysis, the goal of inter-subject analysis (ISA) is to explore the dependency structure between different subjects with the intra-subject dependency as nuisance. ISA has important applications in neuroscience to study the functional connectivity between brain regions under natural stimuli. We propose a modeling framework for ISA that is based on Gaussian graphical models, under which ISA can be converted to the problem of estimation and inference of a partial Gaussian graphical model. The main statistical challenge is that we do not impose sparsity constraints on the whole precision matrix and we only assume the inter-subject part is sparse. For estimation, we propose to estimate an alternative parameter to get around the nonsparse issue and it can achieve asymptotic consistency even if the intra-subject dependency is dense. For inference, we propose an untangle and chord procedure to de-bias our estimator. It is valid without the sparsity assumption on the inverse Hessian of the log-likelihood function. This inferential method is general and can be applied to many other statistical problems, thus it is of independent theoretical interest. Numerical experiments on both simulated and brain imaging data validate our methods and theory. for this article are available online.