Graphical Model Inference with Erosely Measured Data

• 成果类型: Article
• 署名作者: Zheng, Lili; Allen, Genevera I.
• 署名单位: Rice University; Rice University; Rice University; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1080/01621459.2023.2256503
• 发表日期: 2024
• 页码: 2282-2293
• 关键词: false discovery rate; Post-selection Inference; confidence-intervals; COVARIANCE ESTIMATION; regions

摘要

In this article, we investigate the Gaussian graphical model inference problem in a novel setting that we call erose measurements, referring to irregularly measured or observed data. For graphs, this results in different node pairs having vastly different sample sizes which frequently arises in data integration, genomics, neuroscience, and sensor networks. Existing works characterize the graph selection performance using the minimum pairwise sample size, which provides little insights for erosely measured data, and no existing inference method is applicable. We aim to fill in this gap by proposing the first inference method that characterizes the different uncertainty levels over the graph caused by the erose measurements, named GI-JOE (Graph Inference when Joint Observations are Erose). Specifically, we develop an edge-wise inference method and an affiliated FDR control procedure, where the variance of each edge depends on the sample sizes associated with corresponding neighbors. We prove statistical validity under erose measurements, thanks to careful localized edge-wise analysis and disentangling the dependencies across the graph. Finally, through simulation studies and a real neuroscience data example, we demonstrate the advantages of our inference methods for graph selection from erosely measured data. Supplementary materials for this article are available online.