Sparse Independent Component Analysis with an Application to Cortical Surface fMRI Data in Autism

• 成果类型: Article
• 署名作者: Wang, Zihang; Gaynanova, Irina; Aravkin, Aleksandr; Risk, Benjamin B.
• 署名单位: Emory University; University of Michigan System; University of Michigan; University of Washington; University of Washington Seattle
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1080/01621459.2024.2370593
• 发表日期: 2024
• 页码: 2508-2520
• 关键词: source separation; dimensionality; mode; PCA

摘要

Independent component analysis (ICA) is widely used to estimate spatial resting-state networks and their time courses in neuroimaging studies. It is thought that independent components correspond to sparse patterns of co-activating brain locations. Previous approaches for introducing sparsity to ICA replace the non-smooth objective function with smooth approximations, resulting in components that do not achieve exact zeros. We propose a novel Sparse ICA method that enables sparse estimation of independent source components by solving a non-smooth non-convex optimization problem via the relax-and-split framework. The proposed Sparse ICA method balances statistical independence and sparsity simultaneously and is computationally fast. In simulations, we demonstrate improved estimation accuracy of both source signals and signal time courses compared to existing approaches. We apply our Sparse ICA to cortical surface resting-state fMRI in school-aged autistic children. Our analysis reveals differences in brain activity between certain regions in autistic children compared to children without autism. Sparse ICA selects coactivating locations, which we argue is more interpretable than dense components from popular approaches. Sparse ICA is fast and easy to apply to big data. Supplementary materials for this article are available online, including a standardized description of the materials available for reproducing the work.