Efficient evaluation of prediction rules in semi-supervised settings under stratified sampling

• 成果类型: Article
• 署名作者: Gronsbell, Jessica; Liu, Molei; Tian, Lu; Cai, Tianxi
• 署名单位: University of Toronto; Harvard University; Stanford University; Harvard University; Harvard Medical School
• 刊物名称: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY
• ISSN/ISSBN: 1369-7412
• DOI: 10.1111/rssb.12502
• 发表日期: 2022
• 页码: 1353-1391
• 关键词: electronic medical-records; manifold regularization; discovery research; ERROR RATE; biomarkers; regression; accuracy; disease

摘要

In many contemporary applications, large amounts of unlabelled data are readily available while labelled examples are limited. There has been substantial interest in semi-supervised learning (SSL) which aims to leverage unlabelled data to improve estimation or prediction. However, current SSL literature focuses primarily on settings where labelled data are selected uniformly at random from the population of interest. Stratified sampling, while posing additional analytical challenges, is highly applicable to many real-world problems. Moreover, no SSL methods currently exist for estimating the prediction performance of a fitted model when the labelled data are not selected uniformly at random. In this paper, we propose a two-step SSL procedure for evaluating a prediction rule derived from a working binary regression model based on the Brier score and overall misclassification rate under stratified sampling. In step I, we impute the missing labels via weighted regression with nonlinear basis functions to account for stratified sampling and to improve efficiency. In step II, we augment the initial imputations to ensure the consistency of the resulting estimators regardless of the specification of the prediction model or the imputation model. The final estimator is then obtained with the augmented imputations. We provide asymptotic theory and numerical studies illustrating that our proposals outperform their supervised counterparts in terms of efficiency gain. Our methods are motivated by electronic health record (EHR) research and validated with a real data analysis of an EHR-based study of diabetic neuropathy.