STOCHASTIC MODELING IN NANOSCALE BIOPHYSICS: SUBDIFFUSION WITHIN PROTEINS

• 成果类型: Article
• 署名作者: Kou, S. C.
• 署名单位: Harvard University
• 刊物名称: ANNALS OF APPLIED STATISTICS
• ISSN/ISSBN: 1932-6157
• DOI: 10.1214/07-AOAS149
• 发表日期: 2008
• 页码: 501-535
• 关键词: fractional brownian-motion; conformational dynamics; integration; molecules; calculus; Respect

摘要

Advances in nanotechnology have allowed scientists to study biological process on an unprecedented nanoscale molecule-by-molecule basis, opening the door to addressing many important biological problems. A phenomenon observed in recent nanoscale single-molecule biophysics experiments is subdiffusion, which largely departs from the classical Brownian diffusion theory. In this paper, by incorporating fractional Gaussian noise into the generalized Langevin equation, we formulate a model to describe subdiffusion. We conduct a detailed analysis of the model, including (i) a spectral analysis of the stochastic integro-differential equations introduced in the model and (ii) a microscopic derivation of the model from a system of interacting particles. In addition to its analytical tractability and clear physical underpinning, the model is capable of explaining data collected in fluorescence studies on single protein molecules. Excellent agreement between the model prediction and the single-molecule experimental data is seen.