RANKING RELATIONS USING ANALOGIES IN BIOLOGICAL AND INFORMATION NETWORKS

• 成果类型: Article
• 署名作者: Silva, Ricardo; Heller, Katherine; Ghahramani, Zoubin; Airoldi, Edoardo M.
• 署名单位: University of London; University College London; University of Cambridge; Harvard University
• 刊物名称: ANNALS OF APPLIED STATISTICS
• ISSN/ISSBN: 1932-6157
• DOI: 10.1214/09-AOAS321
• 发表日期: 2010
• 页码: 615-644
• 关键词: protein-interaction map; saccharomyces-cerevisiae; yeast; Similarity; expression; complexes; SYSTEM; MODEL

摘要

Analogical reasoning depends fundamentally on the ability to learn and generalize about relations between objects. We develop all approach to relational learning which, given a set of pairs of objects S = {A((1)) : B-(1), A((2)) : B-(2), ..., A((N)) : B-(N)), measures how well other pairs A : B fit in with the set S. Our work addresses the following question: is the relation between objects A and B analogous to those relations found in S? Such questions are particularly relevant in information retrieval, where an investigator might want to search for analogous pairs of objects that match the query set of interest. There are many ways in which objects can be related, making the task of measuring analogies very challenging. Our approach combines a similarity measure on function spaces with Bayesian analysis to produce a ranking. It requires data containing features of the objects of interest and a link matrix specifying which relationships exist; no further attributes of such relationships are necessary. We illustrate the potential of our method on text analysis and information networks. An application on discovering functional interactions between pairs of proteins is discussed in detail, where we show that our approach can work in practice even if a small set of protein pairs is provided.