REGION-REFERENCED SPECTRAL POWER DYNAMICS OF EEG SIGNALS: A HIERARCHICAL MODELING APPROACH

• 成果类型: Article
• 署名作者: Li, Qian; Shamshoian, John; Senturk, Damla; Sugar, Catherine; Jeste, Shafali; DiStefano, Charlotte; Telesca, Donatello
• 署名单位: University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
• 刊物名称: ANNALS OF APPLIED STATISTICS
• ISSN/ISSBN: 1932-6157
• DOI: 10.1214/20-AOAS1374
• 发表日期: 2020
• 页码: 2053-2068
• 关键词: language-acquisition; autism; disorders; synchrony

摘要

Functional brain imaging through electroencephalography (EEG) relies upon the analysis and interpretation of high-dimensional, spatially organized time series. We propose to represent time-localized frequency domain characterizations of EEG data as region-referenced functional data. This representation is coupled with a hierarchical regression modeling approach to multivariate functional observations. Within this familiar setting we discuss how several prior models relate to structural assumptions about multivariate covariance operators. An overarching modeling framework, based on infinite factorial decompositions, is finally proposed to balance flexibility and efficiency in estimation. The motivating application stems from a study of implicit auditory learning, in which typically developing (TD) children, and children with autism spectrum disorder (ASD) were exposed to a continuous speech stream. Using the proposed model, we examine differential band power dynamics as brain function is interrogated throughout the duration of a computer-controlled experiment. Our work offers a novel look at previous findings in psychiatry and provides further insights into the understanding of ASD. Our approach to inference is fully Bayesian and implemented in a highly optimized Rcpp package.