A SEQUENTIAL CLINICAL-TRIAL FOR COMPARING 3 TREATMENTS

• 成果类型: Article
• 署名作者: SIEGMUND, D
• 刊物名称: ANNALS OF STATISTICS
• ISSN/ISSBN: 0090-5364
• DOI: 10.1214/aos/1176349037
• 发表日期: 1993
• 页码: 464-483
• 关键词: weak expansions; BOUNDARY; density

摘要

A model for sequential clinical trials involving three treatments is proposed and various error probabilities are defined. A specific procedure involving a concatenation of repeated significance tests is studied in detail. The first phase of testing proceeds until at least one treatment is eliminated; and then a second phase is used to compare the remaining treatments. Analytic approximations to the operating characteristics of the test are derived and compared with the results of a Monte Carlo experiment.