Estimating disease attack rates in heterogeneous interacting populations, with applications to HIV vaccine trials

• 成果类型: Article
• 署名作者: Wick, D; Self, SG
• 署名单位: Fred Hutchinson Cancer Center
• 刊物名称: ANNALS OF STATISTICS
• ISSN/ISSBN: 0090-5364
• 发表日期: 1997
• 页码: 642-661
• 关键词: infection; issues; RISK

摘要

We describe models for infectious disease attack rates outside Aalen's multiplicative class and incorporating heterogeneity and interactions between subjects. Large-sample theory for the Nelson-Aalen estimator is developed, and its relevance examined in a simulation study. Planning for randomized, controlled clinical trials of prophylactic HIV vaccines partly motivated this work.