An unbiased test for the bioequivalence problem

• 成果类型: Article
• 署名作者: Brown, LD; Hwang, JTG; Munk, A
• 署名单位: University of Pennsylvania; Cornell University; Ruhr University Bochum
• 刊物名称: ANNALS OF STATISTICS
• ISSN/ISSBN: 0090-5364
• 发表日期: 1997
• 页码: 2345-2367
• 关键词: comparative bioavailability trials; equivalence confidence sets; intersection-union tests; intervals; POWER

摘要

It is shown that the standard two one-sided tests procedure for bioequivalence is a biased test. Better tests exist. In this paper, an unbiased alpha-level test and other tests which are uniformly more powerful than the two one-sided tests procedure are constructed. Its power can be noticeably larger than that of the alpha-level two one-sided tests procedure.