SEMIPARAMETRIC EFFICIENT ESTIMATION FOR SHARED-FRAILTY MODELS WITH DOUBLY-CENSORED CLUSTERED DATA

• 成果类型: Article
• 署名作者: Su, Yu-Ru; Wang, Jane-Ling
• 署名单位: Fred Hutchinson Cancer Center; University of California System; University of California Davis
• 刊物名称: ANNALS OF STATISTICS
• ISSN/ISSBN: 0090-5364
• DOI: 10.1214/15-AOS1406
• 发表日期: 2016
• 页码: 1298-1331
• 关键词: PROPORTIONAL HAZARDS MODEL; maximum-likelihood estimators; ASYMPTOTIC THEORY; regression-analysis; survival function; self-consistent; failure time; CONVERGENCE; algorithms; bootstrap

摘要

In this paper, we investigate frailty models for clustered survival data that are subject to both left- and right-censoring, termed doubly-censored data. This model extends current survival literature by broadening the application of frailty models from right-censoring to a more complicated situation with additional left-censoring. Our approach is motivated by a recent Hepatitis B study where the sample consists of families. We adopt a likelihood approach that aims at the non parametric maximum likelihood estimators (NPMLE). A new algorithm is proposed, which not only works well for clustered data but also improve over existing algorithm for independent and doubly-censored data, a special case when the frailty variable is a constant equal to one. This special case is well known to be a computational challenge due to the left-censoring feature of the data. The new algorithm not only resolves this challenge but also accommodates the additional frailty variable effectively. Asymptotic properties of the NPMLE are established along with semi parametric efficiency of the NPMLE for the finite-dimensional parameters. The consistency of Bootstrap estimators for the standard errors of the NPMLE is also discussed. We conducted some simulations to illustrate the numerical performance and robustness of the proposed algorithm, which is also applied to the Hepatitis B data.