Analysis of Mammography Screening Policies under Resource Constraints

• 成果类型: Article
• 署名作者: Cevik, Mucahit; Ayer, Turgay; Alagoz, Oguzhan; Sprague, Brian L.
• 署名单位: University of Wisconsin System; University of Wisconsin Madison; University System of Georgia; Georgia Institute of Technology; University of Vermont
• 刊物名称: PRODUCTION AND OPERATIONS MANAGEMENT
• ISSN/ISSBN: 1059-1478
• DOI: 10.1111/poms.12842
• 发表日期: 2018
• 页码: 949-972
• 关键词: breast-cancer; cost-effectiveness; colorectal-cancer; women; RISK; biopsy; optimization; strategies; benefits; models

摘要

Breast cancer, the leading cause of cancer death for women, can be detected at earlier stages through mammography screening. Therefore, most developed countries implemented population-based mammography screening programs. However, cost of mammography and limited resources in terms of number of trained personnel and diagnostic machines prevent mammography screening to be adopted by many other countries. In fact, even in resource-rich countries, there is a growing concern about cost of mammography screening. In this study, we investigate the optimal allocation of limited mammography resources to screen a population. We propose a constrained partially observable Markov decision process (CPOMDP) model that maximizes total expected quality-adjusted life years of the patients when they are allowed only a limited number of mammography screenings. We use a variable resolution grid-based approximation scheme to convert the CPOMDP model into a mixed-integer linear program and conduct several numerical experiments using breast cancer epidemiology data. We observe that as mammography screening capacity decreases, patients in the 40-49 age group should be given the least priority with respect to screening. We further find that efficient allocation of available resources between patients with different risk levels leads to significant quality-adjusted life year gains, especially for the patients with higher breast cancer risk.