The potential importance of the built- environment microbiome and its impact on human health

• 成果类型: Article
• 署名作者: Bosch, Thomas C. G.; Wigley, Mark; Colomina, Beatriz; Bohannan, Brendan; Meggers, Forrest; Amato, Katherine R.; Azad, Meghan B.; Blaser, Martin J.; Brown, Kate; Dominguez-Bello, Maria Gloria; Ehrlich, Stanislav Dusko; Elinav, Eran; Finlay, B. Brett; Geddie, Kate; Geva-Zatorsky, Naama; Giles-Vernick, Tamara; Gros, Philippe; Guillemin, Karen; Haraoui, Louis Patrick; Johnson, Elizabeth; Keck, Frederic; Lorimer, Jamie; McFall-Ngai, Margaret J.; Nichter, Mark; Pettersson, Sven; Poinar, Hendrik; Rees, Tobias; Tropini, Carolina; Undurraga, Eduardo A.; Zhao, Liping; Melby, Melissa K.
• 署名单位: University of Kiel; Canadian Institute for Advanced Research (CIFAR); Columbia University; Princeton University; University of Oregon; Princeton University; Northwestern University; University of Manitoba; University of Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba; Rutgers University System; Rutgers University New Brunswick; Massachusetts Institute of Technology (MIT); Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; University of London; University College London; Weizmann Institute of Science; Helmholtz Association; German Cancer Research Center (DKFZ); University of British Columbia; Canadian Institute for Advanced Research (CIFAR); Technion Israel Institute of Technology; Technion Israel Institute of Technology; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; McGill University; University of Oregon; University of Sherbrooke; Cornell University; Universite PSL; College de France; University of Oxford; California Institute of Technology; University of Arizona; Nanyang Technological University; McMaster University; University of British Columbia; Pontificia Universidad Catolica de Chile; University of Delaware
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15386
• DOI: 10.1073/pnas.2313971121
• 发表日期: 2024-05-14
• 关键词: buildings; immunity

摘要

There is increasing evidence that interactions between microbes and their hosts not only play a role in determining health and disease but also in emotions, thought, and behavior. Built environments greatly influence microbiome exposures because of their built - in highly specific microbiomes coproduced with myriad metaorganisms including humans, pets, plants, rodents, and insects. Seemingly static built structures host complex ecologies of microorganisms that are only starting to be mapped. These microbial ecologies of built environments are directly and interdependently affected by social, spatial, and technological norms. Advances in technology have made these organisms visible and forced the scientific community and architects to rethink gene-environment and microbe interactions respectively. Thus, built environment design must consider the microbiome, and research involving host-microbiome interaction must consider the built - environment. This paradigm shift becomes increasingly important as evidence grows that contemporary built environments are steadily reducing the microbial diversity essential for human health, well - being, and resilience while accelerating the symptoms of human chronic diseases including environmental allergies, and other more life - altering diseases. New models of design are required to balance maximizing exposure to microbial diversity while minimizing exposure to human - associated diseases. Sustained trans - disciplinary research across time (evolutionary, historical, and generational) and space (cultural and geographical) is needed to develop experimental design protocols that address multigenerational multispecies health and health equity in built environments.